Inhibition of Enzyme Activities by Free Fatty Acids

Inhibition of enzyme activities by free fatty acids.

The inhibition of several enzyme activities by free fatty acids has been examined. The inhibition of rat liver microsomal linolenate-activating enzyme activity by linolenate was found to be due to the inactivation of enzyme by substrate fatty acid. Stearoyl coenzyme A was also found to inhibit linolenate-activating enzyme. Likewise, microsomal glucose 6-phosphatase was inhibited by oleate; the ...

Selective inhibition of bacterial enzymes by free fatty acids.

Octanoic acid inhibits, in vitro, the bacterial enzymes glucose-6-phosphate dehydrogenase, phosphofructokinase, pyruvate kinase, fumarase, lactate dehydrogenase, and the malic enzyme of Arthrobacter crystallopoietes. The free fatty acid appears to act as an inhibitor of lipogenesis, although it does not affect the rate of gluconeogenesis. To demonstrate that this inhibition may be of physiologi...

Inhibition of Thermophilic Anaerobic Digestion of Waste Food by Long Chain Fatty Acids and Propionate

Myocytes by Free Fatty Acids

Using rat ventricular cells, we studied the actions of free fatty acids and their ability to modulate the ATP-sensitive K' channel and to activate a new type of ATP-insensitive K' channel previously identified in rat atrial cells. Perfusion of the cytoplasmic face of the membrane with unsaturated fatty acids (10-50 ,M) such as arachidonic, linoleic, and eicosatrienoic acids inhibited the ATP-se...

Sulfonated porous carbon catalyzed esterification of free fatty acids

The esterification of free fatty acids (FFA) with methanol is studied using Sulfonated Porous Carbon (SPC) as catalyst. In compare to the amorphous sugar catalyst and protonated Nafion, the proposed catalyst shows stability and high efficient performance in biodiesel production. The highest initial rate of oleic acid conversion is obtained at catalyst loading of 1 mmol H+ and mole ra...